periodontal disease

Abstract: It is presently unclear why there is a high prevalence of periodontal disease (PD) in individuals living with chronic kidney disease (CKD). By employing three different models in rats and mice, we demonstrate that experimental uremia causes periodontal bone loss. Uremia alters the biochemical composition of saliva and induces progressive dysbiosis of the oral microbiota, with microbial samples from uremic animals displaying reduced overall bacterial growth, increased alpha diversity, reduced abundance of key components of the healthy oral microbiota such as Streptococcus and Rothia, and an increase in minor taxa including those from gram-negative phyla Proteobacteria and Bacteroidetes....

Abstract: Healthy connective tissues are covered and protected by an epithelium. The single unavoidable exception concerns cementum and dentine at the neck of a tooth after the epithelial attachment migrates past the enamel. Carious lesions break this barrier and microbial invasion via dentine and pulp leads to pulpitis, osteomyelitis and extraction. Similarly, tooth loss from periodontal disease may leave infected bone. Dental implants may thus be placed in prejudiced bone. In the context of this symposium, therefore, the peri-implant disease may be nucleated before the outset....